Multiple factors play important roles in successful tissue regeneration. Conventional tissue engineering approaches mainly use scaffolds and cells to restore functionalities of damaged tissues, but there still are many hurdles regarding the efficacy and side effects by unwanted immune reactions during the treatment and regeneration processes. Immune system also coordinates with microenvironment of cells or organs to direct tissue repair and regeneration. By using advanced biomaterials, we aim to develop novel immune engineering tools to modulate, replace, engineer the systemic or local immune systems for successful tissue regeneration and inflammatory disease treatment.