Biomaterials are engineered substances interacting with biological systems to improve efficacy of various therapeutics. From the surface modification of medical devices to the 3D construct fabrication, we are designing novel biomaterials that are multi-functional, dynamic and triggerable for successful tissue regeneration and disease treatment. Especially, hydrogel, a water containing 3D construct composed of polymeric networks, has shown great potential in versatile biomedical applications by modulating its mechanical and biochemical properties. We develop biological system-inspired hydrogels that are scalable, safe, and bio-functional. We are also interested in the development of advanced tools for biomaterial fabrication.